Orlistat is the active ingredient of weight loss OTC med. Popular brands are Xenical, Alli and Orlistat Stada.
In 2010, the Food and Drug Administration (FDA) published a safety review of orlistat, because of rare reports of serious liver injury in people using orlistat. The FDA found no evidence to confirm that orlistat was the cause of the reported liver injuries.
Orlistat promotes weight loss by decreasing the amount of dietary fat absorbed in your intestines.
Lipase, an enzyme found in the digestive tract, helps break down dietary fat into smaller components, therefore, it can be used or stored for energy. About orlistat, it inhibits the work of lipase. When you take orlistat based med with a meal, about 25 percent of the fat you consume isn’t broken down and is eliminated through bowel movements.